"Levodopa / Benserazid-Teva": instructions for use, analogues and reviews

Than it is possible to replace such a medicine as"Levodopa / Benserazide"? Analogs of this drug will be discussed at the end of the article. We will also present the pharmacological characteristics of this drug, its form of release, indications and methods of application.

levodopa benserazide

Form, composition, packaging

Medicine"Levodopa / Benserazid-Teva", the instruction of which is enclosed in a cardboard box, is available in the form of tablets, packaged in bottles of 30, 20, 60 or 50 pieces. The main substances of this drug are benserazid and levodopa. As for the additional components, they include: mannitol, calcium hydrophosphate (anhydrous), MCC, crospovidone, pregelatinized corn starch, silicon dioxide colloid, povidone K25, magnesium stearate and iron dye red oxide.

Pharmacological characteristics

The drug "Levodopa / Benserazid" is aa combination antiparkinsonian agent that includes a inhibitor of decarboxylase (peripheric) aromatic L-amino acids and a precursor of dopamine.

In parkinsonism, dopamine is released from basal nuclei in insufficient quantities. Its replacement is carried out by taking levodopa, which is a metabolic precursor of dopamine.

The largest part of this element in peripheraltissues is converted to dopamine, which does not participate in the antiparkinsonian effect, as it poorly penetrates the BBB, and is also responsible for most adverse reactions.

Kinetics of the drug

As specialists characterize thea drug, or rather, its kinetic-technological process? Levodopa with benserazid absorbed mainly in the small intestine. When taking the medicine inside, the peak of its concentration is reached after approximately 65 minutes.

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It should be especially noted that the absorption of these elements depends on the intragastric pH, as well as on the rate of excretion of the stomach contents.

When taking levodopa immediately after a meal, its highest concentration in the plasma is approximately 30% less, and the degree of absorption is 15% lower.

In large quantities, this drug is found in the small intestine, kidneys and liver. In this case, only 1% penetrates the brain.

The half-life of the drug in question is three hours.

Unlike levodopa, a component of the drug, like benserazide, does not penetrate the BBB. This substance accumulates in the lung tissue, kidneys, liver and small intestine.

When appoint?

The drug "Levodopa / Benserazid" is antiparkinsonian. Therefore it is advisable to appoint it at:

  • Parkinsonism syndrome (exception is the syndrome caused by taking antipsychotic drugs);
  • Parkinson's disease;
  • restless legs syndrome, including in people with chronic kidney failure who receive dialysis.

levodopa benserazide teva instruction

Prohibitions to use

Are there any contraindications to the medicament "Levodopa / Benserazid-Teva" (testimonials testifying to their validity, we will consider below)? This drug is not prescribed for:

  • mental illness;
  • hypersensitivity to the elements of the agent;
  • severe disruption in the endocrine system, as well as vessels and heart;
  • kidney and liver diseases, except for the development of restless legs syndrome with the joint preparation of dialysis;
  • lactation;
  • glaucoma is closed-angle;
  • parallel application of nonselective MAO inhibitors;
  • pregnancy;
  • under the age of 25;
  • in reproductive age in women who do not use reliable methods of contraception.

"Levodopa / Benserazide": trade name, method of application

You can buy this medication at any pharmacy. The commercial name of this drug is "Levodopa / Benserazid-Teva."

In what dosage is the medication prescribed for patients? Treatment with this drug begins with a small dose, which is gradually increased (for each patient individually).

According to the experts, high doses of this drug should be avoided. The following dosing regimen should be considered as a general recommendation.

technological process of levodopa with benserazide

"Levodopa / Benserazide" should be taken orally at least half an hour before or 65 minutes after a meal.

People who had previously taken this remedy in theThe beginning of therapy is recommended to use 12.5 / 50 mg benserazide and levodopa four times a day. If the drug is well tolerated, this dosage is increased by the same amount every three days. Further selection of the dose is carried out at a frequency of once every 30 days.

As a rule, the therapeutic effect after the application of this drug is noted already with the intake of 100 mg of benserazide and 400 mg of levodopa per day.

The highest dosage of this drug per dayis 800/200 mg of levodopa and benserazide, respectively. This amount of medicine should be divided into 4 or more receptions. At the same time, they should be distributed in such a way as to provide the patient with the optimal therapeutic effect.

If unwanted reactions develop, either increase the dose or reduce it.

Dosage regimen in special clinical cases

How should I take medication"Levodopa / Benserazide"? Experts say that patients experiencing strong motor fluctuations, the daily dose of this drug should be divided by more than 4 admission.

In the elderly, the increase in dosage should be slower.

The experience of using the drug in adolescents and children is limited.

With hepatic and renal failure, correction of the dose of the drug is not required.

 levodopa benserazide trade name

With the development of spontaneous movements, especially in later stages of treatment, it is recommended to reduce dosage. The same goes for the undesirable consequences of the CAS.

Signs of an overdose

Reception of increased doses of the drug"Levodopa / Benserazid", the synonyms of which will be presented below, can cause such symptoms as nausea, arrhythmia, involuntary movements of a pathological nature, insomnia, vomiting, confusion. It should also be noted that the development of such symptoms may be delayed due to a delayed absorption of the drug from the digestive tract.

For the treatment of the described conditions,symptomatic therapy (prescribe antiarrhythmic drugs, respiratory analeptics and neuroleptics), as well as regularly monitor the vital functions of the body.

Interaction

The drug "Levodopa / Benserazid" interacts with other drugs as follows:

  • The administration of trihexyphenidyl reduces the rate, but not the degree of absorption of levodopa.
  • Hypotensive drugs, opioids, neuroleptics and agents containing reserpine, suppress the action of the described drug.
  • The use with antacids helps to reduce the degree of absorption of the agent in question by 32%.
  • Metoclopramide increases the rate of absorption of levodopa.
  • The intake of pyridoxine reduces the antiparkinsonian effect of the drug.
  • It is prohibited to use levodopa and benserazide together with nonselective MAO inhibitors.
  • This drug potentiates the action of sympathomimetics.
  • The intake of levodopa and benserazide with other antiparkinsonian drugs increases the desired and undesirable effects.
    levodopa benserazide analogues

Special Information

Before taking Levodopa / Benserazidea full medical examination should be performed. This is due to the fact that there are a number of diseases in which this drug should be used with extreme caution:

  • In the presence of open-angle glaucoma, the course of therapy does not begin until the patient is completely cured.
  • It is forbidden to abruptly abolish the drug "Halothane", as it may contribute to the development of neuroleptic malignant syndrome with general anesthesia.

It should also be noted that at the very beginning of admissionthe patient's physiological parameters may change. In this regard, during the treatment it is required to regularly take tests to monitor the normal functioning of all internal organs.

People with diabetes should check their blood glucose several times a day.

The cost of the drug and its analogues / synonyms

How much is a medication such as "Levodopa / Benserazid-Teva"? The price of this medicine depends on the number of tablets in the package. As a rule, it varies between 600 and 1250 rubles.

What can be replaced by thean antiparkinsonian drug? Its main analogues and synonyms include the following: Zimox, Duellin, Izik, Nakom, Dopar 275, Karbidopa / Levodopa, Sinemet, Sindopa, Tidomet, Tremonorm. " It should be noted immediately that the pharmacological features and methods of using these drugs can significantly differ from the above. Therefore, replacing them with "Levodopa / Benserazid-Teva" follows only the doctor's recommendations.

levodopa benserazide reviews

Reviews about the effectiveness of the drug

It is not a secret for anyone that Parkinson's disease is an extremely serious disease. In addition, this is a serious test for the patient and his close people.

According to reviews of specialists and consumers,The time of treatment this medication acts on all patients in different ways. Sometimes even under the strict supervision of a doctor with prolonged taking of tablets in sick people, there are increased irritability and attacks of aggression. There are also side reactions in the form of hallucinations and dizziness.

With a decrease in dosage in some patients, signsmental disorders disappear, and the motor function is not disturbed. However, in other patients, even after complete discontinuation of the drug, all mental disorders persist. In addition, their motor function is significantly worse.

In connection with all of the above, it can be safely concluded that when taking the drug in question it is necessary to be ready for the development of serious side effects, which were mentioned above.

According to reports of specialists, the process of treatmentantiparkinsonian drug should only take place under the strict supervision of a doctor. This will allow to track even the slightest changes in the patient's condition from the cardiovascular system and the psyche, and, if necessary, react in a timely manner.

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